Allenic amino acids. 1. Synthesis of. gamma.-allenic GABA by a novel aza-Cope rearrangement

AL Castelhano, A Krantz

Index: Castelhano,A.L.; Krantz,A. Journal of the American Chemical Society, 1984 , vol. 106, p. 1877

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Citation Number: 34

Abstract

1 C= Rq= Hq, R2= CHs reactivity of relevant P, y-acetylenic amines and amino acid^.^,^ Despite the mechanistic rationale for" suicide inhibition", the corresponding allenic amino acids have not been de~ cribed.~,~ This is unfortunate as allenes are of special interest because they can be made chiral and thus offer possibilities for specific enzyme inhibition that are not available to acetylenes.'O We now wish to report the first example of the ...