Oligoribonucleotide (RNA)–carbohydrate conjugates bearing mono-and divalent mannosides were readily obtained using 3, 4-diethoxy-3-cyclobutene-1, 2-dione as the linking agent in the presence of trace amount of triethylamine. The glycoconjugates were purified by HPLC and characterized by electrospray mass spectroscopy.
