Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

…, JF Riou, R Rodriguez, S Balasubramanian

Index: Mueller, Sebastian; Sanders, Deborah A.; Di Antonio, Marco; Matsis, Stephanos; Riou, Jean-Francois; Rodriguez, Raphael; Balasubramanian, Shankar Organic and Biomolecular Chemistry, 2012 , vol. 10, # 32 p. 6537 - 6546

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Citation Number: 45

Abstract

The synthesis, biophysical and biological evaluation of a series of G-quadruplex interacting small molecules based on a N, N′-bis (quinolinyl) pyridine-2, 6-dicarboxamide scaffold is described. The synthetic analogues were evaluated for their ability to stabilize telomeric G- quadruplex DNA, some of which showed very high stabilization potential associated with high selectivity over double-stranded DNA. The compounds exhibited growth arrest of ...