Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives

Y Luo, F Xiao, S Qian, W Lu, B Yang

Index: Luo, Yu; Xiao, Feng; Qian, Shijing; Lu, Wei; Yang, Bo European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 417 - 422

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Citation Number: 20

Abstract

A novel kind of thiazolylbenzimidazole derivatives were designed and synthesized and evaluated for their antitumor activity against SMMC-7721 and A549 cell lines. Most compounds showed good antitumor activities, and compound 11b displayed remarkable in vitro anticancer activity comparable to taxol. The preliminary structure–activity relationship of these benzimidazole derivatives was discussed based on the experimental data obtained.