Imidazo [4, 5-b] pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development …

…, C Sun, N Bouloc, M Kosmopoulou…

Index: Gudmundsson, Kristjan S.; Hinkley, Jack M.; Brieger, Michael S.; Drach, John C.; Townsend, Leroy B. Synthetic Communications, 1997 , vol. 27, # 5 p. 861 - 870

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Citation Number: 45

Abstract

... Finally, 21 was obtained from 20 by treatment with p-methoxybenzaldehyde in the presence of Na 2 S 2 O 4 in ethanol (Scheme 2). figure Scheme 3. a. a Reagents and conditions: (a) EtOH, 1 M aq. Na 2 S 2 O 4 , 80 °C, 16 h; (b) (MeO) 3 CH, conc. ...