Organic letters

Cascade Synthesis of Fenpiprane and Related Pharmaceuticals via Rhodium-Catalyzed Hydroaminomethylation

S Li, K Huang, J Zhang, W Wu, X Zhang

Index: Li, Shengkun; Huang, Kexuan; Zhang, Jiwen; Wu, Wenjun; Zhang, Xumu Organic Letters, 2013 , vol. 15, # 5 p. 1036 - 1039

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Citation Number: 12

Abstract

A novel rhodium catalytic system with Naphos as ligand was developed for an efficient hydroaminomethylation of 1, 1-diphenylethene under relatively mild conditions. This will allow for an atom-economic and environmentally benign synthesis of fenpiprane and related pharmaceuticals.