Discovery of N-[2-hydroxy-6-(4-methoxybenzamido) phenyl]-4-(4-methyl-1, 4-diazepan-1-yl) benzamide (darexaban, YM150) as a potent and orally available factor Xa …

F Hirayama, H Koshio, T Ishihara…

Index: Journal of Medicinal Chemistry, , vol. 54, # 23 p. 8051 - 8065

Full Text: HTML

Citation Number: 23

Abstract

... Journal of Medicinal Chemistry. ... In our search for orally bioavailable FXa inhibitors, we conducted high-throughput screening (HTS) of the library of compounds in the collection of Yamanouchi Pharmaceutical Co., Ltd. ...