3??Oxo??1, 2??benzoisothiazoline??2??acetic acid 1, 1??dioxide derivatives. I. Reaction of esters with alkoxides

CB Schapira, IA Perillo…

Index: Schapira, Celia B.; Perillo, Isabel A.; Lamdan, Samuel Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1281 - 1288

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Citation Number: 21

Abstract

Abstract Reaction of 3-oxo-1, 2-benzoisothiazoline-2-acetic acid alkyl esters 1, 1-dioxide (1a- d) with alkaline alkoxides was carried out under various conditions. Under mild conditions, o- (N-carboxymethylsulfamyl) benzoic acids dialkyl esters (2a-d) were obtained with good yields. Reaction of 1a-d or 2a-d with sodium alkoxides under drastic conditions afforded 4- hydroxy-2H-1, 2-benzothiazine-3-carboxylic acid alkyl esters 1, 1-dioxide (3a-d). ...

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