Preparation of a Corticotropin-Releasing Factor Antagonist by Nucleophilic Aromatic Substitution and Copper-Mediated Ether Formation†

S Caron, NM Do, JE Sieser…

Index: Azuma, Yutaka; Morone, Mieko; Nagayama, Kouki; Kawamata, Yurie; Sato, Atsuko Heterocycles, 2003 , vol. 60, # 6 p. 1461 - 1468

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Citation Number: 16

Abstract

... Volume: Page: ... it was found that addition of a tetrahydrofuran solution of potassium tert-butoxide to a mixture of 2 and 26 and one equivalent of copper(I) iodide in tetrahydrofuran at 60 °C allowed for conversion to diaryl ether 6 with approximately 5 ...