Tetrahedron

Free-radical carbo-oximation of olefins and subsequent radical-ionic cascades

Y Landais, F Robert, E Godineau, L Huet, N Likhite

Index: Landais, Yannick; Robert, Frederic; Godineau, Edouard; Huet, Laurent; Likhite, Nachiket Tetrahedron, 2013 , vol. 69, # 47 p. 10073 - 10080

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Citation Number: 8

Abstract

Abstract A sequential carbo-formylation cascade has been developed, involving a free- radical carbo-oximation process, followed by the hydrolysis of the oxime ether. For this purpose, we designed a new SEM O-protected sulfonyl oxime, which enable both rapid radical addition and hydrolysis under mild conditions. The resulting aldehyde-esters were then engaged in various nucleophilic cascades, such as Sakurai allylations or domino- ...