C-6 aryl substituted 4-quinolone-3-carboxylic acids as inhibitors of hepatitis C virus

…, J Zacharias, R Vince, RJ Geraghty, Z Wang

Index: Chen, Yue-Lei; Zacharias, Jeana; Vince, Robert; Geraghty, Robert J.; Wang, Zhengqiang Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 15 p. 4790 - 4800

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Citation Number: 8

Abstract

Quinolone-3-carboxylic acid represents a highly privileged chemotype in medicinal chemistry and has been extensively explored as antibiotics and antivirals targeting human immunodeficiency virus (HIV) integrase (IN). Herein we describe the synthesis and anti- hepatitis C virus (HCV) profile of a series of C-6 aryl substituted 4-quinlone-3-carboxylic acid analogues. Significant inhibition was observed with a few analogues at low micromolar ...