Tetrahedron: asymmetry

Chemoenzymatic enantioselective synthesis of 3-hydroxy-2-pyrrolidinones and 3-hydroxy-2-piperidinones

A Kamal, KV Ramana, AV Ramana, AH Babu

Index: Kamal, Ahmed; Ramana, K. Venkata; Ramana, A. Venkata; Babu, A. Hari Tetrahedron Asymmetry, 2003 , vol. 14, # 17 p. 2587 - 2594

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Citation Number: 11

Abstract

Hydroxy substituted nitrogen heterocycles containing five- and six-membered rings are well known in nature and are components of many compounds with valuable pharmacological properties. 1., and For instance, these N-substituted pyrrolidinones are of interest for the treatment of brain insufficiencies and as cognition activators. 2 In view of their low toxicities these have recently attracted much attention in the pharmaceutical arena. 3., , , , , , and In addition, ...