Synthesis of 3??[(aryl)??1, 2, 4??oxadiazol??5??yl] propionic acids

RM Srivastava, MBDAB Viana…

Index: Srivastava; Borges Viana de; Bieber Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 1193 - 1195

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Citation Number: 9

Abstract

Abstract Seven 3, 5-disubstituted oxadiazole derivatives, 3a-g, have been prepared by direct condensation of appropriate benzamidoxime with succinic anhydride. Spectroscopic properties, especially uv, ir and mass spectra confirmed the cyclic 1, 2, 4-oxadiazole structure. No ring-opened intermediate or side product could be observed. The 1 H-nmr assignments of the two CH 2 groups were unequivocally made by acid-and base-induced ...