Rhodium/Copper??Catalyzed Annulation of Benzimides with Internal Alkynes: Indenone Synthesis through Sequential C H and C N Cleavage

BJ Li, HY Wang, QL Zhu, ZJ Shi

Index: Li, Bi-Jie; Wang, Hao-Yuan; Zhu, Qi-Lei; Shi, Zhang-Jie Angewandte Chemie - International Edition, 2012 , vol. 51, # 16 p. 3948 - 3952

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Citation Number: 155

Abstract

Indenones are valuable synthetic intermediates for natural products, ligand scaffolds, and material science.[1] Traditional synthetic routes to indenones usually require multiple steps or have limited scope.[2] Transition metal catalyzed approaches have begun to address some of these issues by providing various direct routes for their synthesis.[3, 4] Among these methods, several direct annulation reactions between alkyne and ortho-functionalized ...