Ligand??Free Pd??Catalyzed Highly Selective Arylation of Allylic Esters with Retention of the Traditional Leaving Group

…, W Jia, J Xiao, Q Liu, L Zhang, N Jiao

Index: Pan, Delin; Chen, Anjun; Su, Yijin; Zhou, Wang; Li, Si; Jia, Wei; Xiao, Juan; Liu, Qingjian; Zhang, Liangren; Jiao, Ning Angewandte Chemie - International Edition, 2008 , vol. 47, # 25 p. 4729 - 4732

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Citation Number: 75

Abstract

The Heck reaction [1] has been studied in detail as a powerful tool for the construction of CÀC bonds in organic synthesis.[2] Over the past several decades, the scope of the Heck reaction has been expanded significantly to include aryl chlorides [3] and tosylates,[4] alkyl halides,[5] and arenes (through CÀH activation) as suitable substrates.[6] The Heck reaction can also be carried out regioselectively with electron-rich olefins.[7] However, Pd- ...