Chloro-oxime derivatives as novel small molecule chaperone amplifiers

…, Y Chen, J Pham, T Brady, G Liu, J Chen, J Nam…

Index: Zhou, Yuefen; Vu, Khang; Chen, Yongsheng; Pham, John; Brady, Thomas; Liu, Gang; Chen, Jinhua; Nam, Joonwoo; Murali Mohan Reddy; Au, Qingyan; Yoon, Il Sang; Tremblay, Marie-Helene; Yip, Gary; Cher, Charmian; Zhang, Bin; Barber, Jack R.; Ng, Shi Chung Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 11 p. 3128 - 3135

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Citation Number: 10

Abstract

Chloro-oxime derivatives were investigated as novel small molecule chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC50< 10μM).