Organic letters

Novel and selective palladium-catalyzed annulations of 2-alkynylphenols to form 2-substituted 3-halobenzo [b] furans

Y Liang, S Tang, XD Zhang, LQ Mao, YX Xie…

Index: Liang, Yun; Tang, Shi; Zhang, Xu-Dong; Mao, Li-Qiu; Xie, Ye-Xiang; Li, Jin-Heng Organic Letters, 2006 , vol. 8, # 14 p. 3017 - 3020

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Citation Number: 74

Abstract

A novel and selective palladium-catalyzed annulation of 2-alkynylphenols method for the synthesis of 2-substituted 3-halobenzo [b] furans is presented. In the presence of PdX2, CuX2, and HEt3NX, 2-substituted 3-halobenzo [b] furans were selectively obtained as the major products. The mechanism of the reaction was also discussed.

~17%

~9%

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