Journal of fluorine chemistry

… and derived compounds Part 5. Improved preparations of 1, 2, 3, 4-tetrafluoro-5, 6-dinitrobenzene and 3, 4, 5, 6-tetrafluoro-1, 2-phenylenediamine, and the use of the …

A Heaton, M Hill, F Drakesmith

Index: Heaton, Alan; Hill, Mark; Drakesmith, Frederick Journal of Fluorine Chemistry, 1997 , vol. 81, # 2 p. 133 - 138

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Citation Number: 26

Abstract

The preparation of 2, 3, 4, 5-tetrafluoro-6-nitroaniline (3) by amination of pentafluoronitrobenzene has been speeded up, scaled up and the yield increased by controlling the reaction by TLC monitoring and using 'dry column'chromatography. Compound (3) was readily converted to 1, 2, 3, 4-tetrafluoro-5, 6-dinitrobenzene (2) by peroxytrifluoroacetic acid and to 3, 4, 5, 6-tetrafluoro-1, 2-phenylenediamine (1) by SnCl2/ ...