Tetrahedron

Conversion of 1, 3-disubstituted arenes to chiral α, α-diaryl methylammonium chlorides using arene borylation

TA Boebel, JF Hartwig

Index: Boebel, Timothy A.; Hartwig, John F. Tetrahedron, 2008 , vol. 64, # 29 p. 6824 - 6830

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Citation Number: 23

Abstract

A two-step conversion of 1, 3-disubstituted arenes to chiral α, α-diaryl methylammonium chlorides is described. In this procedure, arenes are converted to aryl boronic esters by iridium-catalyzed borylation, and the aryl boronic esters are converted to enantioenriched amines by subsequent rhodium-catalyzed addition to chiral tert-butanesulfinimes.