Synlett

Metal-free reductive cleavage of NO bonds in Weinreb amides by an organic neutral super-electron donor

…, JA Murphy, H Farwaha, SZ Zhou, E Chrystal

Index: Cutulic, Sylvain P. Y.; Murphy, John A.; Farwaha, Hardeep; Zhou, Sheng-Ze; Chrystal, Ewan Synlett, 2008 , # 14 p. 2132 - 2136

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Citation Number: 14

Abstract

Abstract The scope of neutral organic super-electron donors as reducing agents has been extended to include the reductive cleavage of NO bonds in Weinreb amides. This methodology proved to be applicable to a large array of substrates to afford their reduced counterparts in good to excellent yields. The variation in reactivity within the set of tested amides is rationalised.