Pyrazolo [5, 1-b] quinazolin-9-ones: a new series of antiallergic agents

…, T Capiris, SJ Kesten, DJ Herzig

Index: Sircar, Jagadish C.; Capiris, Thomas; Kesten, Stephen J.; Herzig, David J. Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 735 - 742

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Citation Number: 43

Abstract

A new series of antiallergic agents, pyrazolo [5, 1-b] quinazolin-9-ones, was synthesized and evaluated for inhibitory effects in the rat reaginic passive cutaneous anaphylaxis (PCA) screen. Several analogues were found to be more potent than cromolyn sodium intravenously. Structureactivity relationships are discussed. One of the compounds, 4, 9- dihydro-5-methoxy-9-oxopyrazolo [5, l-~] quin~ oline-2-c~ boxylic acid (36), was found to ...