Tetrahedron letters

Ion-exchange resins for solution phase parallel synthesis of chemical libraries

LM Gayo, MJ Suto

Index: Gayo, Leah M.; Suto, Mark J. Tetrahedron Letters, 1997 , vol. 38, # 4 p. 513 - 516

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Citation Number: 127

Abstract

Described are various techniques that employ ion-exchange resins for the solution-phase synthesis of chemical libraries. We have found these resins to be useful as reagents and/or scavengers in a variety of reactions. Nine basic ion-exchange resins were evaluated for the catalysis and purification of an amide synthesized from an acid chloride. A number of the resins examined provided products in> 95% purity. Acidic ion-exchange resins were also ...