e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron letters
An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2, 3, 4, 5-tetrahydro-4-methyl-3-oxo-1H-1, 4-benzodiazepine-2-acetate
TW Ku, FE Ali, WE Bondinell, KF Erhard, WF Huffman…
Index: Ku, Thomas W.; Ali, Fadia E.; Bondinell, William E.; Erhard, Karl F.; Huffmann, William F.; et al. Tetrahedron Letters, 1997 , vol. 38, # 18 p. 3131 - 3134
An alternate enantiospecific synthesis of methyl (S)-7-tert-butoxycarbonyl-2, 3, 4, 5- tetrahydro-4-methyl-3-oxo-1H-1, 4-benzodiazepine-2-acetate (5) is reported. The key step, which involves an intermolecular displacement of the activated aryl fluoride (9) by L-aspartic acid β-methyl ester, proceeds without racemization.
