Abstract An efficient three component reaction with enaminones, primary amines and aldehydes resulted in easy access to 1, 4-dihydropyridines with different substituents at the 1-, 3-, 4-and 5-positions. Microwaves improved the reaction yield, reducing also considerably the reaction time and the amount of solvent used. Chiral primary amines gave chiral 1-substituted-1, 4-dihydropyridines. The 4-(1-naphthyl) and 4-(phenanthren-9-yl) ...