Monocerin (5) is a polyketide fungal metabolite that exhibits antifungal, insecticidal, and plant pathogenic properties. It has been isolated from several fungal species, including Dreschlera monoceras,[1] D. ravenelii,[2] Exserohilum turcum,[3] and, along with the related fusarentin ethers, for example, 4, from Fusarium larvarum.[4] Polyketide metabolites are pro-