Synthesis and antimicrobial activity of alkylthioalkylmalonic esters

FG Saitkulova, II Lapkin, TS Prokhorova

Index: Saitkulova, F. G.; Lapkin, I. I.; Prokhorova, T. S. Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 3 p. 205 - 206 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 3 p. 319 - 320

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Abstract

In the literature two methods are described for the preparation of alkyithioaikylmalonic esters: by heating of acetyldimethyl sulfide or ~-chlorodialkyl sulfide with sodium-malonic ester for several hours, giving a yield of not more than I0-35% [3]. The disadvantages of these methods