e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Helvetica chimica acta

A novel rearrangement of 2 (5H)??furanones

RA Mack, TR DeCory, VS Georgiev

Index: Mack; DeCory; Georgiev Helvetica Chimica Acta, 1988 , vol. 71, # 4 p. 783 - 787

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Citation Number: 2

Abstract

Abstract A novel rearrangement of 2 (5H)-furanones is described. When refluxed in aq. Ethanolic solution in the presence of excess KOH, the 2, 5-dihydro-2-oxofuran-3- carboxamides 6 underwent a novel rearrangement to the corresponding 4, 5-dihydro-4-oxo-

2,5-dihydro-N-(o-methoxyphenyl)-2-oxo-4-[N-(m-trifluoromethylphenyl)amino]-3-furancarboxamide Structure

2,5-dihydro-N-(...

~61%

2-(2-methoxyanilino)-4-oxofuran-3-carboxylic acid Structure

2-(2-methoxyani...

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2,5-dihydro-2-oxo-N-phenyl-4-[(N-phenyl-N-methyl)amino]-3-furancarboxamide Structure

2,5-dihydro-2-o...

~75%

2-ANILINO-4-OXO-4,5-DIHYDROFURAN-3-CARBOXYLIC ACID Structure

2-ANILINO-4-OXO...

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N/A Structure

~75%

2-ANILINO-4-OXO-4,5-DIHYDROFURAN-3-CARBOXYLIC ACID Structure

2-ANILINO-4-OXO...

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N/A Structure

~84%

2-ANILINO-4-OXO-4,5-DIHYDROFURAN-3-CARBOXYLIC ACID Structure

2-ANILINO-4-OXO...

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4-[N-(p-chlorophenyl)amino]-2,5-dihydro-2-oxo-N-phenyl-3-furancarboxamide Structure

4-[N-(p-chlorop...

~40%

2-ANILINO-4-OXO-4,5-DIHYDROFURAN-3-CARBOXYLIC ACID Structure

2-ANILINO-4-OXO...

4-Chloroaniline Structure

4-Chloroaniline

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4-[(p-chlorophenyl)amino]-2,5-dihydro-2-oxo-N-(trans-2-phenylcyclopropyl)-3-furancarboxamide Structure

4-[(p-chlorophe...

~43%

2-ANILINO-4-OXO-4,5-DIHYDROFURAN-3-CARBOXYLIC ACID Structure

2-ANILINO-4-OXO...

4-Chloroaniline Structure

4-Chloroaniline

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N-phenyl-2,5-dihydro-2-oxo-4-(N-phenylamino)-3-furancarboxamide Structure

N-phenyl-2,5-di...

~47%

2-ANILINO-4-OXO-4,5-DIHYDROFURAN-3-CARBOXYLIC ACID Structure

2-ANILINO-4-OXO...

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