Design and Synthesis of Aza??Flavones as a New Class of Xanthine Oxidase Inhibitors

R Dhiman, S Sharma, G Singh, K Nepali…

Index: Dhiman, Rajni; Sharma, Sahil; Singh, Gagandip; Nepali, Kunal; Singh Bedi, Preet Mohinder Archiv der Pharmazie, 2013 , vol. 346, # 1 p. 7 - 16

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Citation Number: 21

Abstract

Abstract In an attempt to develop non-purine-based xanthine oxidase (XO) inhibitors, keeping in view the complications reported with the use of purine-based XO inhibitors, the flavone framework (a class possessing XO inhibitory potential) was used as lead structure for further optimization. By means of structure-based classical bioisosterism, quinolone was used as an isoster for chromone (a bicyclic unit present in flavones), owing to the bioactive ...