One??Pot Three??Component Catalytic Synthesis of Fully Substituted Pyrroles from Readily Available Propargylic Alcohols, 1, 3??Dicarbonyl Compounds and Primary …

V Cadierno, J Gimeno, N Nebra

Index: Cadierno, Victorio; Gimeno, Jose; Nebra, Noel Chemistry - A European Journal, 2007 , vol. 13, # 35 p. 9973 - 9981

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Citation Number: 76

Abstract

Abstract A simple and highly efficient method for the preparation of fully substituted pyrroles, from readily accessible secondary propargylic alcohols, 1, 3-dicarbonyl compounds and primary amines, has been developed. The one-pot multicomponent reaction, which is catalysed by the system [Ru (η 3-2-C 3 H 4 Me)(CO)(dppf)][SbF 6]/CF 3 CO 2 H (dppf: 1, 1′- bis (diphenylphosphanyl) ferrocene), involves initial propargylation of the 1, 3-dicarbonyl ...