Tetrahedron

Reactions of hydroxyglycines. New synthetic routes to 4-phenylquinazoline derivatives

AJ Hoefnagel, H van Koningsveld, F van Meurs…

Index: Hoefnagel; Van Koningsveld; Van Meurs; Peters; Sinnema; Van Bekkum Tetrahedron, 1993 , vol. 49, # 31 p. 6899 - 6912

Full Text: HTML

Citation Number: 13

Abstract

Reaction of hydroxyglycine with 2-aminobenzophenones gives 1, 2-dihydro-4-phenyl- quinazoline-2-carboxylic acids in high yields and under mild conditions. These can be smoothly converted into the corresponding 3, 4-dihydro isomers and into quinazoline derivatives via rearrangement and oxidation by air, respectively. The X-ray crystallographic structure of 6-chloro-1, 2-dihydro-1-methyl-4-phenylquinazoline-2-carboxylic acid shows ...