Tetrahedron

Direct Aromatic tert-Butylation during the Synthesis of Thiochroman-4-ones

SE Clayton, CD Gabbutt, JD Hepworth, BM Heron

Index: Clayton, Stephen E.; Gabbutt, Christopher D.; Hepworth, John D.; Mark Heron Tetrahedron, 1993 , vol. 49, # 4 p. 939 - 946

Full Text: HTML

Citation Number: 40

Abstract

The synthesis of thiochroman-4-ones from thiophenols and 3-methylbut-2-enoic acid effected by methane sulphonic acid is accompanied by tert-butylation of the aromatic ring. 3- Arylthiobutanoic acids, available using β-butyrolactone, are efficiently cyclised in the same manner.