A series of optically pure 1, 3-dioxolane nucleoside mimics was synthesized by a synthetic route that allowed incorporation of a 5R-methyl substituent from commercially available starting materials. The pyrrolo [2, 3-d] pyrimidine heterocycle was chosen as a substitute for the purine derivative. Coupling of the pyrrolo [2, 3-d] pyrimidine and the dioxolane was performed under solid–liquid phase transfer conditions. The ability to inhibit HCV RNA ...
