Organic letters

Palladium-catalyzed direct arylation of nitro-substituted aromatics with aryl halides

L Caron, LC Campeau, K Fagnou

Index: Caron, Laurence; Campeau, Louis-Charles; Fagnou, Keith Organic Letters, 2008 , vol. 10, # 20 p. 4533 - 4536

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Citation Number: 93

Abstract

ABSTRACT Direct arylation reactions of nitrobenzenes and aryl halides occur in good yield and high ortho regioselectivity. These reactions can be performed on gram scale with as few as 3 equiv of the nitro arene relative to the aryl halide. The synthetic utility of this method is demonstrated via rapid synthesis of a Boscalid intermediate.