Reaction of Grignard Compounds with 4-Chloro-2-methyl-3-butyn-2-ol in Diethyl Ether Equivalents

SA Shchelkunov, OA Sivolobova, SO Mataeva…

Index: Shchelkunov; Sivolobova; Mataeva; Minbaev; Muldakhmetov Russian Journal of Organic Chemistry, 2001 , vol. 37, # 1 p. 5 - 8

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Citation Number: 1

Abstract

Abstract Reactions of RMgX· THF complexes with 4-chloro-2-methyl-3-butyn-2-ol in aromatic hydrocarbons were studied. The complexes formed by arylmagnesium halides require the presence of anisole for the reaction to occur. 4-Chloro-2-methyl-3-butyn-2-ol can be synthesized by reaction of 2-methyl-3-butyn-2-ol with sodium hypochloride in the two-phase system water-benzene.

 Related Synthetic Route
4-chloro-2-methylbut-3-yn-2-ol Structure

29552-15-6

4-chloro-2-meth...

2-Bromotoluene Structure

95-46-5

2-Bromotoluene

~%

2-Methyl-4-o-tolylbut-3-yn-2-ol Structure

40888-14-0

2-Methyl-4-o-to...

3-Methyl butynol Structure

115-19-5

3-Methyl butynol

~%

2-Methyl-4-o-tolylbut-3-yn-2-ol Structure

40888-14-0

2-Methyl-4-o-to...

Bromocyclohexane Structure

108-85-0

Bromocyclohexane

4-chloro-2-methylbut-3-yn-2-ol Structure

29552-15-6

4-chloro-2-meth...

~48%

2-cyclohexylacetylene Structure

931-48-6

2-cyclohexylace...

1-Bromodecane Structure

112-29-8

1-Bromodecane

4-chloro-2-methylbut-3-yn-2-ol Structure

29552-15-6

4-chloro-2-meth...

~53%

1-Dodecyne Structure

765-03-7

1-Dodecyne

1-Bromooctane Structure

111-83-1

1-Bromooctane

4-chloro-2-methylbut-3-yn-2-ol Structure

29552-15-6

4-chloro-2-meth...

~59%

dec-1-yne Structure

764-93-2

dec-1-yne

4-chloro-2-methylbut-3-yn-2-ol Structure

29552-15-6

4-chloro-2-meth...

1-Bromododecane Structure

143-15-7

1-Bromododecane

~54%

1-Tetradecyne Structure

765-10-6

1-Tetradecyne

4-chloro-2-methylbut-3-yn-2-ol Structure

29552-15-6

4-chloro-2-meth...

3-Bromotoluene Structure

591-17-3

3-Bromotoluene

~63%

2-methyl-4-(3-methylphenyl)but-3-yn-2-ol Structure

63079-66-3

2-methyl-4-(3-m...

3-Methyl butynol Structure

115-19-5

3-Methyl butynol

~%

2-methyl-4-(3-methylphenyl)but-3-yn-2-ol Structure

63079-66-3

2-methyl-4-(3-m...

3-Methyl butynol Structure

115-19-5

3-Methyl butynol

~91%

4-chloro-2-methylbut-3-yn-2-ol Structure

29552-15-6

4-chloro-2-meth...

4-chloro-2-methylbut-3-yn-2-ol Structure

29552-15-6

4-chloro-2-meth...

4-Bromotoluene Structure

106-38-7

4-Bromotoluene

~%

2-methyl-4-(4-methylphenyl)but-3-yn-2-ol Structure

79756-91-5

2-methyl-4-(4-m...

3-Methyl butynol Structure

115-19-5

3-Methyl butynol

~%

2-methyl-4-(4-methylphenyl)but-3-yn-2-ol Structure

79756-91-5

2-methyl-4-(4-m...


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