e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Selective mono-arylation and-alkylation of chlorophenyl alkyl sulfides by nickel catalysed cross-coupling with grignard reagents

…, L Testaferri, M Tingoli, D Chianelli, E Wenkert

Index: Tiecco, Marcello; Testaferri, Lorenzo; Tingoli, Marco; Chianelli, Donatella; Wenkert, Ernest Tetrahedron Letters, 1982 , vol. 23, # 44 p. 4629 - 4632

Full Text: HTML

Citation Number: 36

Abstract

This document does not have an outline. ... JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. ... Author links open the overlay panel. Numbers correspond to the affiliation list which can be exposed by using the show more link. ... Chlorophenyl alkyl sulfides are mono-arylated and -alkylated selectively with Grignard reagents, in the presence of Ni(PPh 3 ) 2 Cl 2 , to give aryl- and alkyl-phenyl alkyl sulfides.

4-Chlorophenyl methyl sulfide Structure

4-Chlorophenyl ...

Allyl(bromo)magnesium Structure

Allyl(bromo)mag...

~34%

p-diisopropenylbenzene Structure

p-diisopropenyl...

Thioanisole Structure

Detail

1,4-Dichlorobenzene Structure

1,4-Dichlorobenzene

~%

1-methylsulfanyl-4-prop-2-enylbenzene Structure

1-methylsulfany...

1-chloro-2-propan-2-ylsulfanylbenzene Structure

1-chloro-2-prop...

METHYLMAGNESIUM BROMIDE Structure

METHYLMAGNESIUM...

~63%

1-(Isopropylsulfanyl)-2-methylbenzene Structure

1-(Isopropylsul...

1,2-Dichlorobenzene Structure

1,2-Dichlorobenzene

~%

1-(Isopropylsulfanyl)-2-methylbenzene Structure

1-(Isopropylsul...

1,4-Dichlorobenzene Structure

1,4-Dichlorobenzene

~%

3-(4-BIPHENYL)-1-PROPENE Structure

3-(4-BIPHENYL)-...

4-Chlorophenyl methyl sulfide Structure

4-Chlorophenyl ...

~%

3-(4-BIPHENYL)-1-PROPENE Structure

3-(4-BIPHENYL)-...

1-methylsulfanyl-4-phenylbenzene Structure

1-methylsulfany...

Allyl(bromo)magnesium Structure

Allyl(bromo)mag...

~49%

3-(4-BIPHENYL)-1-PROPENE Structure

3-(4-BIPHENYL)-...

isopropyl 3-chlorophenyl sulfide Structure

isopropyl 3-chl...

METHYLMAGNESIUM BROMIDE Structure

METHYLMAGNESIUM...

~51%

Sulfide, isopropyl m-tolyl Structure

Sulfide, isopro...

1,3-Dichlorobenzene Structure

1,3-Dichlorobenzene

~%

Sulfide, isopropyl m-tolyl Structure

Sulfide, isopro...

1,4-Dichlorobenzene Structure

1,4-Dichlorobenzene

~%

1-methyl-4-(4-phenylphenyl)benzene Structure

1-methyl-4-(4-p...

1-Chloro-4-(isopropylsulfanyl)benzene Structure

1-Chloro-4-(iso...

~%

1-methyl-4-(4-phenylphenyl)benzene Structure

1-methyl-4-(4-p...

1,4-Dichlorobenzene Structure

1,4-Dichlorobenzene

~%

1-methylsulfanyl-4-phenylbenzene Structure

1-methylsulfany...

1-Chloro-4-(isopropylsulfanyl)benzene Structure

1-Chloro-4-(iso...

METHYLMAGNESIUM BROMIDE Structure

METHYLMAGNESIUM...

~61%

Isopropyl 4-methylphenyl sulfide Structure

Isopropyl 4-met...

1,4-Dichlorobenzene Structure

1,4-Dichlorobenzene

~%

Isopropyl 4-methylphenyl sulfide Structure

Isopropyl 4-met...