Heteroatom Chemistry

Enantioselective reduction of dialkyl 4??(dialkoxyphosphoryl)??3??oxobutanoates by baker's yeast

C Yuan, K Wang, J Li, Z Li

Index: Yuan, Chengye; Wang, Ke; Li, Jinfeng; Li, Zuyi Heteroatom Chemistry, 2002 , vol. 13, # 2 p. 153 - 156

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Citation Number: 14

Abstract

Abstract Dialkyl 4-(dialkoxyphosphoryl)-3-oxobutanoates (1), upon yeast-mediated bioreduction, afforded chiral dialkyl 4-(dialkoxyphosphoryl)-3-hydroxybutanoates (2) in moderate to good yields and ee values. Significant improvement was reported for the preparation of dialkyl 4-(dialkoxyphosphoryl)-3-oxobutanoates (1), the key substrates of this bioreductive conversion.© 2002 Wiley Periodicals, Inc. Heteroatom Chem 13: 153–156, ...