Synthesis of dinitro-substituted furans, thiophenes, and azoles

…, J Sivapackiam, B Draghici, R Damavarapu

Index: Katritzky, Alan R.; Vakulenko, Anatoliy V.; Sivapackiam, Jothilingam; Draghici, Bogdan; Damavarapu, Reddy Synthesis, 2008 , # 5 p. 699 - 706

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Citation Number: 11

Abstract

Abstract Direct nitration of the corresponding mononitro furans with fuming nitric acid, thiophenes with acetyl nitrate, and thiazoles with trifluoroacetyl nitrate, gave dinitro- substituted furans, thiophenes, and thiazoles. The nitrations of 2-alkylthiophenes with 3 and 5 molar equivalents of acetyl nitrate, generated in situ, are discussed. Reactions of the mononitro furans with fuming nitric acid gave 1, 1, 5, 5-tetrasubstituted dihydrofurans as by ...