An Improved Access to 4??Trifluoromethyl??2 (1H)??quinolinones: The “Watering Protocol”

…, O Lefebvre, M Schlosser

Index: Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred European Journal of Organic Chemistry, 2004 , # 1 p. 54 - 63

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Citation Number: 19

Abstract

Abstract Condensation of anilines with ethyl 4, 4, 4-trifluoroacetoacetate (7) to afford the corresponding 4, 4, 4-trifluoro-3-oxobutaneanilides (10), precursors to 4-(trifluoromethyl)-2- quinolinones (11), can be favored and the competing condensation to produce the ethyl 4, 4, 4-trifluoro-3-(phenylimino) butanoate, the precursor to 2-(trifluoromethyl)-4-quinolinones, avoided if water is occasionally added to the reaction mixture while ethanol is ...