Mannich-Type Reaction of N, O-Acetals with Ketones Mediated by a Combination of TiCl4 and PhSiCl3

…, M Kuriyama, Y Matsumura, S Kamogawa

Index: Kamogawa, Satoshi; Ikeda, Takashi; Kuriyama, Masami; Matsumura, Yoshihiro; Onomura, Osamu Heterocycles, 2010 , vol. 82, # 1 p. 325 - 332

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Citation Number: 6

Abstract

A combination of TiCl4 and PhSiCl3 efficiently conducts the Mannich-type reaction of N, O- acetals with ketones to afford α-substituted cyclic amine derivatives in good yields. This method was applicable to preparation of azabicyclo compounds by the intramolecular Mannich-type reaction.