Tetrahedron letters

Mg-promoted mixed pinacol coupling

…, Y Yamamoto, H Shimada, K Yonemura, I Nishiguchi

Index: Maekawa, Hirofumi; Yamamoto, Yoshimasa; Shimada, Hisashi; Yonemura, Kazuaki; Nishiguchi, Ikuzo Tetrahedron Letters, 2004 , vol. 45, # 20 p. 3869 - 3872

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Citation Number: 35

Abstract

Mg-promoted reduction of a mixture of aromatic ketones (or imines) and aliphatic carbonyl compounds in N, N-dimethylformamide (DMF) brought about unique mixed pinacol type of cross coupling to give unsymmetrical vicinal diols (or amino alcohols) or α-hydroxyketones in good to moderate yields. The reaction may be initiated by electron transfer from magnesium metal to an aromatic carbonyl compound possessing a less negative ...