The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis x

PV Murphy, RE Hubbard, DT Manallack…

Index: Murphy, Paul V.; Hubbard, Rod E.; Manallack, David T.; Wills, Ruth E.; Montana, John G.; Taylor, Richard J. K. Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 12 p. 2421 - 2439

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Citation Number: 14

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The design and synthesis of a series of analogues of sialyl Lewis x (1) which incorporate conformationally rigid tetralin and naphthalene ring systems (2–4) has led to novel compounds which have similar potency to 1 as inhibitors of cell adhesion.