Synthesis and protein degradation capacity of photoactivated enediynes

…, JK Wyatt, A El-Shafey, G Hynd, CF Crasto…

Index: Fouad, Farid S.; Wright, Justin M.; Plourde II, Gary; Purohit, Ajay D.; Wyatt, Justin K.; El-Shafey, Ahmed; Hynd, George; Crasto, Curtis F.; Lin, Yiqing; Jones, Graham B. Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 9789 - 9797

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Citation Number: 43

Abstract

The viability of proteins as targets of thermally and photoactivated enediynes has been confirmed at the molecular level. Model studies using a labeled substrate confirmed the efficacy of atom transfer from diyl radicals produced from enediynes to form captodatively stabilized carbon centered aminoacyl radicals, which then undergo either fragmentation or dimerization. To exploit this finding, a family of enediynes was developed using an ...