Molecules

2-(Substituted phenyl)-3, 4-dihydroisoquinolin-2-iums as novel antifungal lead compounds: Biological evaluation and structure-activity relationships

…, R Yang, C Zhang, LF Zhu, F Miao, XJ Yang, L Zhou

Index: Hou, Zhe; Yang, Rui; Zhang, Cen; Zhu, Li-Fei; Miao, Fang; Yang, Xin-Juan; Zhou, Le Molecules, 2013 , vol. 18, # 9 p. 10413 - 10424

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Citation Number: 14

Abstract

Abstract: The title compounds are a class of structurally simple analogues of quaternary benzo [c] phenanthridine alkaloids (QBAs). In order to develop novel QBA-like antifungal drugs, in this study, 24 of the title compounds with various substituents on the N-phenyl ring were evaluated for bioactivity against seven phytopathogenic fungi using the mycelial growth rate method and their SAR discussed. Almost all the compounds showed definite ...