New. MU.-Opioid Receptor Agonists with Piperazine Moiety.

…, T Okada, S Sato, Y Niino, T Oka, T Sakamoto

Index: Komoto; Okada; Sato; Niino; Oka; Sakamoto Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 10 p. 1314 - 1320

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Citation Number: 12

Abstract

New μ-opioid receptor (MOR) agonists containing piperazine and homopiperazine moieties in the structures were synthesized and their affinities to and agonist potencies on MOR were evaluated. Among the synthesized compounds, 4-[4-(2-methoxyphenyl) piperazin-1-yl]-N, N- dimethyl-2, 2-diphenylbutanamide (20Aa) showed the highest affinity to the human MOR expressed in Chinese hamster ovary (CHO)-K1 cells, and the highest agonist potency on ...