Discovery and optimization of novel 4-[(aminocarbonyl) amino]-N-[4-(2-aminoethyl) phenyl] benzenesulfonamide ghrelin receptor antagonists

A Pasternak, SD Goble, DL Hreniuk, CC Chung…

Index: Pasternak, Alexander; Goble, Stephen D.; deJesus, Reynalda K.; Hreniuk, Donna L.; Chung, Christine C.; Tota, Michael R.; Mazur, Paul; Feighner, Scott D.; Howard, Andrew D.; Mills, Sander G.; Yang, Lihu Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 21 p. 6237 - 6240

Full Text: HTML

Citation Number: 15

Abstract

... 2; (a) WP Esler, J. Rudolph, TH Claus, W. Tang, N. Barucci, S.-E. Brown, W. Bullock, M. Daly, L. DeCarr, Y. Li, L. Milardo, D. Molstad, J. Zhu, SJ Gardell, JN Livingston, LJ Sweet; Endocrinology, 148 (2007), pp. 5175–5185. ... b) K. Dezaki, H. Hosoda, M. Kakei, S. Hashiguchi, M. Watanabe, et al. Diabetes, 53 (2004), pp. 3142–3151. ...