Synthesis and biological activity of n-butylphthalide derivatives

…, J Reiner, Y Gao, HL Qiao, JX Shen, JB Chang

Index: Wang, Wei; Cha, Xue-Xiang; Reiner, John; Gao, Yuan; Qiao, Hai-Ling; Shen, Jia-Xiang; Chang, Jun-Biao European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 1941 - 1946

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Citation Number: 24

Abstract

A series of n-butylphthalide derivatives were designed and synthesized. The in vitro activities of these compounds were evaluated by a resting tension of isolated rat thoracic aorta ring assay. Compounds 4g and 4i were found to be more active than n-butylphthalide. ... A series of n-butylphthalide derivatives were designed and synthesized. The activities of these compounds were evaluated. ... Cardiovascular and cerebrovascular disorders are the main reason ...