An efficient synthesis of 1-(2-methoxyphenoxy)-2, 3-epoxypropane: key intermediate of β-adrenoblockers

LR Madivada, RR Anumala, G Gilla…

Index: Madivada, Lokeswara Rao; Anumala, Raghupathi Reddy; Gilla, Goverdhan; Kagga, Mukkanti; Bandichhor, Rakeshwar Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1660 - 1664

Full Text: HTML

Citation Number: 3

Abstract

In general, synthetic approaches to the active pharmaceutical ingredients (APIs) ought to be safer, simple, and cost-effective. From the process development standpoint, in-depth optimization efforts tend to offer several advantages (eg, robustness, use of nontoxic solvents, less energy intensive, etc.) in the manufacturing of the drug substances. ... In order to exemplify an application of epoxypropane (4) in the synthesis of ranolazine (1), we embarked our studies on the ...