A new class of potent farnesyltransferase inhibitors based on a 1, 4-diazepane scaffold was synthesized with protein farnesyltransferase inhibition potencies in the low nanomolar range. The compounds block the growth on two hormone-resistant tumor prostatic cell lines (DU145 and PC3). The advanced cellular evaluation of the more potent farnesyltransferase inhibitors was explored and revealed a disorganization of tubulin in PC3 cells.
![[1-(4-trifluoromethylbenzyl)-1H-5-imidazolyl]methyl acetate Structure](https://image.chemsrc.com/caspic/319/833490-35-0.png)
![[3-[[4-(trifluoromethyl)phenyl]methyl]imidazol-4-yl]methanol Structure](https://image.chemsrc.com/caspic/243/833490-37-2.png)
