Tetrahedron

Copper catalyzed/mediated synthetic methodology for ebselen and related isoselenazolones

SJ Balkrishna, BS Bhakuni, S Kumar

Index: Balkrishna, Shah Jaimin; Bhakuni, Bhagat Singh; Kumar, Sangit Tetrahedron, 2011 , vol. 67, # 49 p. 9565 - 9575

Full Text: HTML

Citation Number: 36

Abstract

Scope of the copper catalyzed/mediated selenium-nitrogen coupling reaction has been studied for the synthesis of isoselenazolones. It is noticed that the 2-chloro, 2-bromo-, and 2- iodo-aryl amides substrates can be exploited in the selenium–nitrogen coupling reaction by employing 25–100 mol% of CuI/1, 10-phenanthroline (L) and potassium carbonate as a base in DMF. Furthermore, electron rich 2-chloro-arylamides also underwent selenium– ...