Total synthesis of polyether antibiotics. Synthesis of the enantiomer of lasalocid A (X-537A)

…, L Courtney, BJ Fitzsimmons

Index: Ireland, Robert E.; Courtney, Lawrence; Fitzsimmons, Brian J. Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5186 - 5198

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Citation Number: 44

Abstract

In a previous report3 from these laboratories, the total synthesis of the antibiotic ionophore lasalocid A was presented. The basic design of this synthesis was predicated on a desire to define a synthetic strategy that could be applied to the construction of other polyether antibiotics, both natural and nonnatural. An example of the use of this strategy for the construction of a synthetic lasalocid analogue, ent-X537A, is reported here. Lasalocid A is ...